Skip to content
David Sinclair’s Longevity Stack: Why NMN Tops the List
Key Takeaways
-
David Sinclair takes NMN daily to support energy, cellular health, and longevity.
-
His supplement stack includes resveratrol, metformin, spermidine, and more.
-
These supplements target the hallmarks of aging—like mitochondrial decline and inflammation.
-
Learn how you can apply the latest science to your own longevity protocol.
Meet David Sinclair: The Scientist Redefining Aging
Dr. David Sinclair, Harvard geneticist and author of Lifespan, believes aging is a disease—and it’s treatable. He’s not just talking the talk; he follows a strict supplement routine based on the latest research.
“Aging is a loss of information. Reboot the system and you restore youth.” — David Sinclair
Let’s explore the supplements Sinclair follows daily to slow the clock down.
What Supplements Does David Sinclair Take?
If you've ever wondered, what supplements does David Sinclair take?—here’s the rundown:
-
NMN (Nicotinamide Mononucleotide) – boosts NAD+ for cellular energy
-
Resveratrol – powerful antioxidant, works with NMN
-
Metformin – supports insulin sensitivity, reduces inflammation
-
Spermidine – promotes autophagy (cellular recycling)
-
Vitamin K2 – for bone health and arterial flexibility
-
Alpha Lipoic Acid – enhances mitochondrial function
-
Low-dose Aspirin – may lower the risk of heart disease
Each of these is part of a longevity supplement stack that targets specific age-related pathways.
Why NMN Leads the Charge
NMN supplements are front and center in Sinclair’s protocol. Why?
-
NMN is a precursor to NAD+, a coenzyme crucial for metabolism and DNA repair.
-
NAD+ declines with age—taking NMN helps replenish it.
-
Sinclair takes 1 gram of NMN each morning, mixed into yogurt for better absorption.
NAD+ fuels sirtuins—the longevity genes that keep cells functioning like they did in your 20s.
NMN + Resveratrol = Powerful Anti-Aging Duo
David Sinclair doesn’t just take NMN. He pairs it with resveratrol, a compound found in red wine that:
-
Activates sirtuins, which regulate cellular health
-
Works synergistically with NMN to enhance gene repair
-
Is best absorbed when taken with fat—another reason he mixes it with yogurt
Bonus tip: Many NMN users report better results when paired with resveratrol!
The Role of Metformin in Sinclair’s Routine
Metformin is a surprising addition to Sinclair’s supplement protocol:
-
Originally a diabetes drug, it’s shown potential to reduce the risk of cancer and heart disease
-
Sinclair takes 800 mg in the evening, skipping it on workout days to avoid interference with muscle growth.
Metformin may reduce blood sugar spikes and help manage inflammation and methylation.
Infographics: David Sinclair's Supplement Stack: At-A-Glance
| Supplement | Purpose | Dosage & Timing | Notes |
|---|---|---|---|
| Metformin | Blood sugar management, anti-aging | 800 mg in the evening | Skips on workout days |
| NMN | NAD+ boosting, energy metabolism | Morning (empty stomach) | Combined with resveratrol |
| Resveratrol | SIRT1 activation, cellular health | Morning with fat (like yogurt or olive oil) | Enhances NMN effectiveness |
| Vitamin D3 | Bone health, immune function | Morning | Often taken with Vitamin K2 |
| Quercetin | Senolytic, antioxidant | Cycled use | Often paired with fisetin |
| Fisetin | Senolytic, anti-aging support | Cycled use | Senescence cell clearing |
Other Key Players: Sinclair’s Full Supplement Stack
Let’s not forget the supporting cast:
-
Spermidine: enhances cell renewal and autophagy
-
Vitamin K2: essential for bone and vascular health
-
Alpha Lipoic Acid: a powerful antioxidant that protects mitochondria
-
TMG (Trimethylglycine): taken to balance methylation from high-dose NMN
These ingredients support brain health, mitochondrial resilience, and overall anti-aging benefits.
FAQs
What NMN brand does David Sinclair use?
Sinclair hasn’t endorsed a specific brand, but he prefers powdered NMN taken with yogurt.
Why combine NMN and resveratrol?
Together, they activate sirtuins and boost NAD+, delivering synergistic longevity benefits.
What’s the deal with metformin?
He takes it for its anti-aging effects, but skips it on gym days to protect muscle function.
Should I be taking TMG with NMN?
Yes, if you’re taking high doses of NMN, TMG helps support methylation pathways.
Conclusion: Start Your Own Longevity Protocol
David Sinclair’s supplement routine isn’t just hype—it’s backed by decades of research into aging and cellular health. From NMN and resveratrol to metformin and spermidine, his stack targets the biological roots of aging.
🔍 Ready to optimize your health and extend your vitality?
Explore premium, science-backed NMN supplements at Just Glow. Your cells will thank you.
Because healthy aging isn't a dream—it's a decision.
Summary
Curious about how one of the world’s top aging researchers hacks his biology to live longer? Let’s dive into David Sinclair’s supplement routine—and why NMN supplements are at the heart of it all.
