What is NMN benefits?

WHO Recognizes Aging as a Disease: NMN as a Promising Anti-Aging Compound

In 2023, the World Health Organization officially recognized aging as a disease in its International Classification of Diseases. This recognition opens up new avenues for innovative treatments that can delay or reverse age-related diseases such as cancer, cardiovascular disease, metabolic disorders, and neurodegeneration. Among these promising treatments is NMN, highlighted in Harvard geneticist David Sinclair’s book, "Lifespan: Why We Age – and Why We Don’t Have To," which has brought NMN to the forefront as a significant anti-aging substance.

Let's explore the clinical trial results and efficacy of NMN that support these claims.

NMN: Repairing Damaged DNA

NMN (Nicotinamide Mononucleotide) is a naturally occurring metabolite found in small amounts in foods like avocados, mushrooms, and shrimp. Harvard geneticist and co-director of the Paul F. Glenn Center for Biology of Aging, Dr. David Sinclair, along with scientists from the University of New South Wales, continues to research NMN. Dr. Sinclair emphasizes NMN's safety, mentioning in an interview that he takes NMN himself and feels 24 years younger biologically, experiencing more vitality than before. He has also administered NMN to his family; his 79-year-old father became more active, engaging in activities like traveling and rafting after a year of NMN intake.

NMN to NAD: The Secret to DNA Repair

The key to NMN's ability to repair damaged DNA lies in its conversion to NAD+ (Nicotinamide Adenine Dinucleotide). NAD+ is a crucial coenzyme in cellular redox reactions, essential for cellular respiration and energy production. While our bodies produce NAD+, levels drop by half by middle age. Studies show that NMN supplementation increases NAD+ levels, which in turn reduces age-related inflammation in adipose tissue, enhances insulin secretion and action, and improves mitochondrial function and neural health.

NMN’s Proven Benefits and Supporting Research

Delaying Aging

A 2016 animal study revealed that NMN supplementation improved metabolism, prevented age-related weight gain, enhanced vision, increased insulin sensitivity, and prevented changes in age-related gene expression.

Delaying Stem Cell Aging

Research indicates that NMN's ability to raise NAD+ levels helps delay the senescence of brain stem cells, aiding in the preservation of adult neurogenesis, which is crucial for combating age-related cognitive decline and neurodegenerative diseases.

Stabilizing Blood Sugar

Insulin is vital for managing diabetes and maintaining normal blood sugar levels. In a 2021 study at Washington University, 25 overweight and obese women aged 55 to 75 with prediabetes were divided into two groups: one taking 250mg of NMN daily and a placebo group. After 10 weeks, the NMN group showed a 25% improvement in glucose tolerance compared to the placebo group, highlighting NMN's potential in diabetes prevention.

Improving Skin Health

A 2022 study at Doshisha University in Japan with 17 women aged around 55 showed that NMN supplementation over eight weeks reduced advanced glycation end-products (AGEs), which are closely linked to skin aging, suggesting NMN's benefits for skin health.

Preventing Cardiovascular Disease

Aging reduces blood vessel elasticity and increases arterial stiffness, leading to cardiovascular diseases. A clinical trial by DHC, a Japanese skincare company, showed that NMN intake slowed the pulse wave velocity in the ankles, indicating reduced arterial stiffness and improved vascular health.

Enhancing Brain Health

A 2017 study demonstrated that NMN treatment within 30 minutes of a brain hemorrhage reduced neuronal death, brain swelling, oxidative stress, and inflammation. This suggests NMN not only protects the brain from damage but also aids in long-term recovery.

Conclusion

NMN shows a wide range of positive effects on the human body, garnering attention from those interested in anti-aging. If you are concerned about the declining levels of NAD+ due to aging, incorporating NMN supplements into your daily routine could be a beneficial preventive measure. For more information, check out the link below!